Compounds > N-[5-[[5-[(4-acetyl-1-piperazinyl)-oxomethyl]-4-methoxy-2-methylphenyl]thio]-2-thiazolyl]-4-[(3-3-dimethylbutan-2-ylamino)methyl]benzamide

N-[5-[[5-[(4-acetyl-1-piperazinyl)-oxomethyl]-4-methoxy-2-methylphenyl]thio]-2-thiazolyl]-4-[(3-3-dimethylbutan-2-ylamino)methyl]benzamide and Hypersensitivity

N-[5-[[5-[(4-acetyl-1-piperazinyl)-oxomethyl]-4-methoxy-2-methylphenyl]thio]-2-thiazolyl]-4-[(3-3-dimethylbutan-2-ylamino)methyl]benzamide has been researched along with Hypersensitivity* in 1 studies

Other Studies

1 other study(ies) available for N-[5-[[5-[(4-acetyl-1-piperazinyl)-oxomethyl]-4-methoxy-2-methylphenyl]thio]-2-thiazolyl]-4-[(3-3-dimethylbutan-2-ylamino)methyl]benzamide and Hypersensitivity

Article	Year
Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors. Bioorganic & medicinal chemistry letters, 2006, Jul-15, Volume: 16, Issue:14 A series of structurally novel aminothiazole based small molecule inhibitors of Itk were prepared to elucidate their structure-activity relationships (SARs), selectivity, and cell activity in inhibiting IL-2 secretion in a Jurkat T-cell assay. Compound 3 is identified as a potent and selective Itk inhibitor which inhibits anti-TCR antibody induced IL-2 production in mice in vivo and was previously reported to reduce lung inflammation in a mouse model of ovalbumin induced allergy/asthma. Topics: Animals; Asthma; Cells, Cultured; Enzyme Inhibitors; Humans; Hypersensitivity; Jurkat Cells; Mice; Pneumonia; Protein-Tyrosine Kinases; Structure-Activity Relationship; Sulfides; Thiazoles	2006

Article

Year

Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors.

Bioorganic & medicinal chemistry letters, 2006, Jul-15, Volume: 16, Issue:14

A series of structurally novel aminothiazole based small molecule inhibitors of Itk were prepared to elucidate their structure-activity relationships (SARs), selectivity, and cell activity in inhibiting IL-2 secretion in a Jurkat T-cell assay. Compound 3 is identified as a potent and selective Itk inhibitor which inhibits anti-TCR antibody induced IL-2 production in mice in vivo and was previously reported to reduce lung inflammation in a mouse model of ovalbumin induced allergy/asthma.

Topics: Animals; Asthma; Cells, Cultured; Enzyme Inhibitors; Humans; Hypersensitivity; Jurkat Cells; Mice; Pneumonia; Protein-Tyrosine Kinases; Structure-Activity Relationship; Sulfides; Thiazoles

2006